Home >> Antibodies >> A20 / TNFAIP3 (Marker of Tamoxifen Resistance)

A20 / TNFAIP3 (Marker of Tamoxifen Resistance)

Mouse Monoclonal Antibody [Clone TNFAIP3/2813]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).

Formalin-fixed, paraffin-embedded human hepatocellular carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).

Formalin-fixed, paraffin-embedded human breast carcinoma stained with TNFAIP3 Mouse Monoclonal Antibody (TNFAIP3/2813).

Product Details

Synonyms

A20; Putative DNA-binding protein A20; TNF alpha-induced protein 3 (TNFAIP3); Tumor Necrosis Factor alpha-Induced Protein 3(TNFAIP3); Zinc finger protein A20

Positive Control

Hodgkin s Lymphoma or hepatocellular carcinoma (HCC).

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT) ,(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 241-356) of human TNFAIP3 protein (exact sequence is proprietary)

Cellular Localization

Cytoplasmic, Cell Surface and Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

90kDa

Specificity & Comments

A20 (also known as TNFAIP3) is a zinc finger protein and inhibits NF-kappa B activation as well as TNF-mediated apoptosis. The protein has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. A20 is as a tumor suppressor and has been shown to protect MCF-7 breast carcinoma cells from TNF-induced apoptosis. HighA20expression levels were observed in more aggressive breast tumors (ER-negative, progesterone receptor-negative and high histological grade). These findings strongly suggest that A20 is a key protein involved in tamoxifen resistance.