Home >> Antibodies >> Aurora B (Proliferation Marker)

Aurora B (Proliferation Marker)

Mouse Monoclonal Antibody [Clone AURKB/1592]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human Colon stained with Aurora B Mouse Monoclonal Antibody (AURKB/1592).

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Aurora B Mouse Monoclonal Antibody (AURKB/1592).

SDS-PAGE Analysis Purified Aurora B Mouse Monoclonal Antibody (AURKB/1592). Confirmation of Integrity and Purity of Antibody.

Formalin-fixed, paraffin-embedded human Colon stained with Aurora B Mouse Monoclonal Antibody (AURKB/1592).

Formalin-fixed, paraffin-embedded human Prostate Carcinoma stained with Aurora B Mouse Monoclonal Antibody (AURKB/1592).

SDS-PAGE Analysis Purified Aurora B Mouse Monoclonal Antibody (AURKB/1592). Confirmation of Integrity and Purity of Antibody.

Product Details

Synonyms

AIK2; AIM-1; ARK-2; AurB; AURKB; Aurora-1; Aurora and Ipl1 like midbody associated protein 1; Aurora kinase B; Aurora-B; Aurora-related kinase 2; Aurora/IPL1-related kinase 2; IPL1; Protein phosphatase 1 regulatory subunit 48 (PPP1R48); Serine/threonine-protein kinase 12; Serine/threonine-protein kinase aurora-B; STK1; STK12; STK5

Positive Control

HeLa cells. Tonsil, Placenta, Hodgkin s Lymphoma or Colon Carcinoma.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant fragment (around aa 89-251) of human Aurora B protein (exact sequence is proprietary)

Cellular Localization

Nuclear and Cytoplasmic

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

39kDa

Specificity & Comments

Recognizes a protein of 39kDa, which is identified as Aurora B. The serine/threonine protein kinase aurora B (Aurora B) is a chromosomal passenger protein critical for accurate chromosome segregation, cytokinesis, protein localization to the centromere and kinetochore, correct microtubule-kinetochore attachment, and regulation of the mitotic checkpoint. Aurora B forms a tight complex with inner centrosome protein and survivin. Inactivation of any of these proteins causes similar defects in chromosome segregation. A significant overexpression of Aurora B has been found in a variety of human tumors including non-small cell lung carcinoma, astrocytoma, seminoma and carcinomas of the colon, prostate, endometrium and thyroid. The expression level of Aurora B is associated with cell proliferation and prognosis in these tumors.