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Formalin-fixed, paraffin-embedded human Bladder Carcinoma stained with B2M Rabbit Recombinant Monoclonal Antibody (B2M/1857R).
SDS-PAGE Analysis PurifiedB2M Rabbit Recombinant Monoclonal Antibody (B2M/1857R). Confirmation of Purity and Integrity of Antibody.
Flow Cytometric Analysis of human HeLa cells using Beta-2-Microglobulin Rabbit Recombinant Monoclonal Antibody (B2M/1857R) followed by goat anti-mouse IgG-CF488 (Blue); Isotype control (Red).
Western Blot Analysis of THP-1 and Raji cell lysate using B2M Rabbit Recombinant Monoclonal Antibody (B2M/1857R).
Immunofluorescence Analysis of PFA fixed HeLa cells labeling with Beta-2-Microglobulin Rabbit Recombinant Monoclonal Antibody (B2M/1857R); followed by goat anti-rabbit IgG-CF488 (Green).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
Recognizes a protein of 12kDa, identified as beta-2 microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an alphaheavy chain that contains three subdomains (alpha1, alpha2, alpha3) and a non-covalent associating light chain, known as beta-2-Microglobulin. Beta-2-Microglobulin associates with the alpha3 subdomain of the alphaheavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The alpha1 and alpha2 domains of the alphaheavy chain form the peptide antigen-binding cleft. Mutations in the beta-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
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