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SDS-PAGE Analysis Purified Cyclin A2 Mouse Monoclonal Antibody (E67). Confirmation of Integrity and Purity of Antibody.
Formalin-fixed, paraffin-embedded human Endometrium stained with Cyclin A2 Mouse Monoclonal Antibody (E67).
Western Blot Analysis of HeLa cell lysate using Cyclin A2 Mouse Monoclonal Antibody (E67).
Product Details
Synonyms
Positive Control
Known Applications & Suggested Dilutions
Immunogen
Cellular Localization
Species Reactivity
Host / Ig Isotype
Mol. Weight of Antigen
Specificity & Comments
It recognizes a protein of 54kDa, which is identified as cyclin A. Its epitope is located amino acids 144-148 of human Cyclin A2. Cyclins are regulatory subunits of the cyclin-dependent kinases (cdk's) and they control transition at different specific phases of the cell cycle. The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. These cyclin/cdk complexes are essential for passage through specific stages in the cell cycle. In mammalian somatic cells, cyclin A is required for S-phase and passage through G2-phase. The D and E type cyclins regulate the passage of G1, while cyclin B is a critical regulator of mitosis. Mutation or disruption of normal cyclin A expression causes cells to arrest in G2-phase.
Key References
