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FOXL2

Recombinant Rabbit Monoclonal Antibody [Clone FOXL2/8701R]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human parathyroid stained with FOXL2 Recombinant Rabbit Monoclonal Antibody (FOXL2/8701R). HIER: Tris/EDTA, pH9.0, 45min. 2: HRP-polymer, 30min. DAB, 5min.

Product Details

Synonyms

Blepharophimosis epicanthus inversus and ptosis 1; BPES 1; BPES; BPES1; Epicanthus inversus and ptosis 1; Forkhead box protein L2; Forkhead transcription factor FOXL2; PFRK; PINTO; PITUITARY FORKHEAD FACTOR; POF3

Positive Control

Nuclear expression in ovarian follicular and stromal cells. Granulosa cell tumor.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)
(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human FOXL2 protein

Cellular Localization

Nucleus.

Species Reactivity

Human.

Host / Ig Isotype

Rabbit / IgG, kappa

Mol. Weight of Antigen

38kDa

Specificity & Comments

FOXL2 is a critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. It prevents trans-differentiation of ovary to testis through transcriptional repression of the sertoli cell-promoting gene SOX9. FOXL2 is mainly expressed in ovary, parathyroid gland and sex cord-stromal tumors. FOXL2 is generally used for diagnosis of sex cord-stromal tumors with Inhibin, Calretinin and SF-1.