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Home >> Antibodies >> Liver X Receptor beta (LXRB) (Orphan Receptor)

Liver X Receptor beta (LXRB) (Orphan Receptor)

Mouse Monoclonal Antibody [Clone LXRB/2731]

Catalog #

Size

20 ug
100 ug
100 ug

Price (USD)

219.00
499.00
499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Catalog No

Size

20 ug
100 ug
100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml
Purified Ab with BSA and Azide at 200ug/ml
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00
499.00
499.00
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SDS-PAGE Analysis Purified LX Receptor beta Mouse Monoclonal Antibody (LXRB/2731). Confirmation of Purity and Integrity of Antibody.

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Analysis of Protein Array containing >19,000 full-length human proteins using LX Receptor beta (NR1H2) Mouse Monoclonal Antibody (LXRB/2731)

Product Details

Synonyms

Liver X nuclear receptor beta; Liver X receptor beta; LX receptor beta; LXR beta; LXRB; NER1; Nuclear orphan receptor LXR beta; Nuclear receptor NER; Nuclear receptor subfamily 1 group H member 2 (NR1H2); OR-1; Oxysterols receptor LXR-beta; RIP15; Steroid hormone nuclear receptor NER; Ubiquitously-expressed nuclear receptor (UNR)

Positive Control

HeLa, SW480 or A549 cells. Liver.

Known Applications & Suggested Dilutions

ELISA         More Details

ELISA (For coating, order Ab without BSA)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human NR1H2 (LXRB) protein

Cellular Localization

Nuclear

Species Reactivity

Human.

Host / Ig Isotype

Mouse / IgG2c, kappa

Mol. Weight of Antigen

56kDa

Specificity & Comments

The liver X receptors, LXRA (NR1H3) and LXRB (NR1H2) form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors and regulate expression of target genes containing LXR response elements. LXRB can inhibit proliferation and induce apoptosis of cancer cells.

Related Products



200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.

Key References

  1. Bobin-Dubigeon C, Chauvin A, Brillaud-Meflah V, Boiffard F, Joalland MP, Bard JM. Liver X Receptor (LXR)-regulated Genes of Cholesterol Trafficking and Breast Cancer Severity. Anticancer Res. 2017;37(10):5495-5498.

Bioinformatics

  •  Entrez Gene ID: 7376
  •  Gene Symbol: NR1H2
  •  SwissProt: P55055
  •  Chromosome Location: 19q13.33
  •  Unigene: 432976
NBT02731