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MAGE-1 (Target for Cancer Immunotherapy)

Mouse Monoclonal Antibody [Clone MA454]

Printable

Key References

Bioinformatics

Catalog #

Size

20 ug

100 ug

Price (USD)

219.00

499.00

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Performance Guarantee

Catalog No

Size

20 ug

100 ug

Formulation

Purified Ab with BSA and Azide at 200ug/ml

Purified Ab WITHOUT BSA and Azide at 1.0mg/ml

Price (USD)

219.00

499.00

Printable

Key References

Bioinformatics

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Mouse Monoclonal Antibody (MA454).

SDS-PAGE Analysis Purified MAGE-1 Mouse Monoclonal Antibody (MA454). Confirmation of Integrity and Purity of Antibody

Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with MAGE-1 Mouse Monoclonal Antibody (MA454).

SDS-PAGE Analysis Purified MAGE-1 Mouse Monoclonal Antibody (MA454). Confirmation of Integrity and Purity of Antibody

Product Details

Synonyms

MZ2 E, cancer/testis antigen 1.1, CT1.1, MAGE1A, MAGEA1, Melanoma antigen family A 1, Melanoma associated antigen 1, Melanoma associated antigen MZ2 E

Positive Control

Melanoma cell lines. Melanomas or testicular carcinomas.

Known Applications & Suggested Dilutions

IHC-P More Details

Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)
Optimal dilution for a specific application should be determined.

Immunogen

Recombinant full-length human MAGE-A1 protein

Cellular Localization

Cytoplasmic

Species Reactivity

Human. Rat. Dog.

Host / Ig Isotype

Mouse / IgG1, kappa

Mol. Weight of Antigen

42-46kDa

Specificity & Comments

Recognizes a protein of 42-46kDa, identified as MAGE-1. This MAb does not cross-react with MAGE-2, -3, -4, -6 -9, -10, -or -12 protein. Human malignant neoplasms carry rejection antigens that are recognized by the patients' autologous, tumor directed and specific, cytolytic, CD8+ T lymphocyte clones (CTL). The MAGE family of genes codes an important group of antigens. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs). Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.